Pluribus follows Albuquerque author Carol Sturka, who is one of only 13 people in the world immune to the effects of the "Joining", an event in which an extraterrestrial virus transformed the rest of humanity into a peaceful and content hive mind known as the "Others". The hive mind happily accommodates the wishes of those who remain unaffected, but admits that it will ultimately seek to assimilate them when it learns how to do so. Carol is adamantly against their efforts as she searches for a way to reverse the Joining.

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